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However, some mild side effects may occur, especially during the adjustment period or at higher doses: Headaches Temporary injection site irritation Lightheadedness Water retention (in rare cases) Mild tingling or numbness (from elevated IGF-1) Ipamorelin induced growth hormone release without elevating cortisol or ACTH levels, suggesting minimal off-target effects. Raun et al., European Journal of Endocrinology Compared to Other Peptides Unlike GHRP6 , which often causes intense hunger and spikes in prolactin , or GHRP2 , which can increase cortisol , Ipamorelin is more targeted and stable

References [1] Bailey SW, Ayling JE

Tumor metastasis to lymph nodes requires YAP-dependent metabolic adaptation

Many of these substances are known triggers of mast cell activation, so reactions to medications can be the medication (the active ingredient) or can be due to an excipient

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